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Did you mean lc and adenocarcinoma (2,865 results)?
LCK inhibition downregulates YAP activity and is therapeutic in patient-derived models of cholangiocarcinoma.
Conboy CB, Yonkus JA, Buckarma EH, Mun DG, Werneburg NW, Watkins RD, Alva-Ruiz R, Tomlinson JL, Guo Y, Wang J, O'Brien D, McCabe CE, Jessen E, Graham RP, Buijsman RC, Vu D, de Man J, Ilyas SI, Truty MJ, Borad M, Pandey A, Gores GJ, Smoot RL. Conboy CB, et al. J Hepatol. 2023 Jan;78(1):142-152. doi: 10.1016/j.jhep.2022.09.014. Epub 2022 Sep 24. J Hepatol. 2023. PMID: 36162702 Free article.
The Hippo pathway effector, Yes-associated protein (YAP), is oncogenic in CCA, but has historically been difficult to target therapeutically. Recently, we described a novel role for the LCK proto-oncogene, Src family tyrosine kinase (LCK) in activating YAP through t …
The Hippo pathway effector, Yes-associated protein (YAP), is oncogenic in CCA, but has historically been difficult to target therapeutically …
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O. Dey G, et al. J Ovarian Res. 2023 Jun 27;16(1):122. doi: 10.1186/s13048-023-01194-2. J Ovarian Res. 2023. PMID: 37370140 Free PMC article.
LCK expression is induced and activated in the nucleus in response to DNA damage insult. ...Importantly, attenuation of LCK sensitizes HR-proficient eEOC cells to PARP inhibitor in cells and pre-clinical mouse studies. ...
LCK expression is induced and activated in the nucleus in response to DNA damage insult. ...Importantly, attenuation of LCK se …
Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia.
Creeden JF, Alganem K, Imami AS, Henkel ND, Brunicardi FC, Liu SH, Shukla R, Tomar T, Naji F, McCullumsmith RE. Creeden JF, et al. Int J Mol Sci. 2020 Nov 21;21(22):8823. doi: 10.3390/ijms21228823. Int J Mol Sci. 2020. PMID: 33233470 Free PMC article. Review.
Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes across a wide variety of human diseases. In pancreatic ductal adenocarcinoma (PDAC), innovative pharmaceutical strategies such as kinase …
Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes acr …
YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity.
Sugihara T, Werneburg NW, Hernandez MC, Yang L, Kabashima A, Hirsova P, Yohanathan L, Sosa C, Truty MJ, Vasmatzis G, Gores GJ, Smoot RL. Sugihara T, et al. Mol Cancer Res. 2018 Oct;16(10):1556-1567. doi: 10.1158/1541-7786.MCR-18-0158. Epub 2018 Jun 14. Mol Cancer Res. 2018. PMID: 29903769 Free PMC article.
Likewise, inducible CRISPR/Cas9-targeted LCK deletion decreased YAPY357 phosphorylation and its nuclear localization. The importance of LCK in CCA biology was demonstrated by clinical observations suggesting LCK expression levels were associated with early tu …
Likewise, inducible CRISPR/Cas9-targeted LCK deletion decreased YAPY357 phosphorylation and its nuclear localization. The importance …
Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature.
Hinchcliff E, Paquette C, Roszik J, Kelting S, Stoler MH, Mok SC, Yeung TL, Zhang Q, Yates M, Peng W, Hwu P, Jazaeri A. Hinchcliff E, et al. Cancer Immunol Immunother. 2019 Sep;68(9):1515-1526. doi: 10.1007/s00262-019-02385-x. Epub 2019 Sep 12. Cancer Immunol Immunother. 2019. PMID: 31515669 Free PMC article.
Differentially expressed genes in LCK high samples and gene ontology enrichment were analyzed. RESULTS: High pre-treatment LCK mRNA expression was found to be a strong predictor of survival in a set of 535 ovarian cancers. ...Unexpectedly, LCK high samples al …
Differentially expressed genes in LCK high samples and gene ontology enrichment were analyzed. RESULTS: High pre-treatment LCK …
Identification of novel prognosis-related genes in the endometrial cancer immune microenvironment.
Ma J, Zhang JK, Yang D, Ma XX. Ma J, et al. Aging (Albany NY). 2020 Nov 6;12(21):22152-22173. doi: 10.18632/aging.104083. Epub 2020 Nov 6. Aging (Albany NY). 2020. PMID: 33159014 Free PMC article.
The results showed that LCK metagene expression is related to the prognosis of patients with endometrioid endometrial adenocarcinoma subtypes and highly correlated with the PTEN and PIK3CA mutational status. A search for LCK-related modules returned seven ind …
The results showed that LCK metagene expression is related to the prognosis of patients with endometrioid endometrial adenocarcino …
Identifying Immune-Specific Subtypes of Adrenocortical Carcinoma Based on Immunogenomic Profiling.
Lu Q, Nie R, Luo J, Wang X, You L. Lu Q, et al. Biomolecules. 2023 Jan 4;13(1):104. doi: 10.3390/biom13010104. Biomolecules. 2023. PMID: 36671489 Free PMC article.
Several proteins, such as mTOR, ERCC1, Akt, ACC1, Cyclin_E1, beta-catenin, FASN, and GAPDH, were more highly expressed in Immunity-L than in Immunity-H. In contrast, p53, Syk, Lck, PREX1, and MAPK were more highly expressed in Immunity-H. Pathway and gene ontology analysis …
Several proteins, such as mTOR, ERCC1, Akt, ACC1, Cyclin_E1, beta-catenin, FASN, and GAPDH, were more highly expressed in Immunity-L than in …
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Src Family Kinases in Hepatocellular Carcinoma.
Yao D, Deng Y, Zhang S, Liang L, Zhang L, Weng S, Chen S. Yao D, et al. Front Biosci (Landmark Ed). 2023 May 11;28(5):90. doi: 10.31083/j.fbl2805090. Front Biosci (Landmark Ed). 2023. PMID: 37258470 Free article.
Approximately 10% genetic alterations rate of SFKs was observed in HCC. The mRNA levels of BLK, BRK, FRK, FYN, LCK, LYN, SRC, SRM and YES were correlated with clinical cancer stage. ...
Approximately 10% genetic alterations rate of SFKs was observed in HCC. The mRNA levels of BLK, BRK, FRK, FYN, LCK, LYN, SRC, SRM and …
Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations.
Chhikara BS, Ashraf S, Mozaffari S, St Jeans N, Mandal D, Tiwari RK, Ul-Haq Z, Parang K. Chhikara BS, et al. Molecules. 2020 May 2;25(9):2135. doi: 10.3390/molecules25092135. Molecules. 2020. PMID: 32370213 Free PMC article.
Antiproliferative activity of the compounds was evaluated on human leukemia (CCRF-CEM), human ovarian adenocarcinoma (SK-OV-3), breast carcinoma (MDA-MB-231), and colon adenocarcinoma (HT-29) cells in vitro. 4-Chlorophenyl carbo-enyl substituted 3-phenylpyrazolopyri …
Antiproliferative activity of the compounds was evaluated on human leukemia (CCRF-CEM), human ovarian adenocarcinoma (SK-OV-3), breas …
Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma.
Rao CV, Xu C, Farooqui M, Zhang Y, Asch AS, Yamada HY. Rao CV, et al. Cancers (Basel). 2021 May 25;13(11):2586. doi: 10.3390/cancers13112586. Cancers (Basel). 2021. PMID: 34070461 Free PMC article.
Among the 39 CNA- and survival-associated genes, the purine metabolism (PPAT, PAICS), immune-regulating CD4-LCK-MEC2C and CCL14-CCR1 axes, and ALOX5 emerged as survival-critical pathways. These findings revealed a broad role of the immune system in suppressing CIN/CNA and …
Among the 39 CNA- and survival-associated genes, the purine metabolism (PPAT, PAICS), immune-regulating CD4-LCK-MEC2C and CCL14-CCR1 …
62 results